POWER Methyl B12 is manufactured in a Federal Drug Registered and State Board Pharmacy cGMP laboratory
• Support for Central and Peripheral Nervous System
• Support for Healthy Red Blood Cells
• Immune Enhancement
• Supports Healthy Methylation
• Supports Healthy Sleep Patterns
POWER Methyl B12 is a pleasant-tasting, orange-flavored, sublingual tablet of vitamin B12 in its bioidentical form. Studies show greater tissue deposition of cobalamin taken in the methylcobalamin form in comparison to cyanocobalamin. Protocols for a variety of neurological conditions require large doses of vitamin B12 making this 5 mg (5000 mcgs) very convenient.
The only ways to obtain vitamin B12 are from pre-formed vitamin synthesized in the gut by natural flora, from foods derived from other animals, or from supplementation. Unlike other water-soluble vitamins, the liver stores vitamin B12 (4 to 6 mg) bound to a protein as methylcobalamin or 5’-deoxyadenosylcobalamin. In time, reserve stores may become depleted following poor dietary intake without supplementation, gastric surgery, lack of intrinsic factor, or any other reason for poor intestinal absorption.
Methylcobalamin and adenosylcobalamin are the two coenzyme forms of vitamin B12. Methylcobalamin participates in transmethylation reactions. As a cofactor in the enzyme methionine synthase it functions in the regeneration of methionine by transferring its methyl group to homocysteine. Methylcobalamin is the most active of all B12 homologs in the body with respect to nucleic acid and protein and lipid metabolism. Specifically, it is involved in the isomerization of methylmalonyl CoA to Succinyl CoA, a step in the degradation of the amino acids valine, isoleucine, threonine, and fatty acids with an odd number of carbon atoms. If the vitamin is deficient, abnormal fatty acids could be incorporated into cell membranes, including those of the nervous system.
Vitamin B12 aids in repair of damaged nerve tissue in disorders such as axonal degeneration and demyelination.
Methylcobalamin also improves megaloblastic (pernicious) anemia through its involvement in erythroblast maturation, promotion of erythroblast division, and heme synthesis. Deficiency of the vitamin does not allow for the efficient use of the N5-methyl form of tetrahydrofolate for the synthesis of nucleotides needed for DNA replication for the synthesis of red blood cells.
Many vitamin B12 supplements on the market contain cyanocobalamin. The liver is able to convert a small amount of cyanocobalamin to methylcobalamin; however, according to research demonstrating the requirement for high doses, the amount is not sufficient to correct neurological defects or to prevent neurological aging. It has been shown that the amount of cobalamin that accumulates in liver tissue following administration of a small oral dose of methylcobalamin is significantly greater than that following the same dose of cyanocobalamin. Furthermore, the tissues retain a greater amount of cobalamin from methylcobalamin than from cyanocobalamin as concluded from a study showing urinary excretion of one third less methylcobalamin.
2. Yamazaki K, Oda K, Endo C, Kikuchi T, Wakabayashi. Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mouse. Neurosci Lett. 1994 Mar 28;170(1):195-7.
3. Watkins D, Rosenblatt DS. Functional methionine synthase deficiency (cblE and cblG): clinical and biochemical heterogeneity. Am J Med Genet. 1989 Nov;34(3):427-34 [PMID: 2688421]
4. Kira J, Tobimatsu S, Goto I. Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple sclerosis. Intern Med. 1994 Feb;33(2):82-6. [PMID: 8019047]
5. Tamura J, Kubota K, Murakami H, Sawamura M, Matsushima T, Tamura T, Saitoh T, Kurabayshi H, Naruse T. Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol. 1999 Apr; 116 (1): 28-32 [PMID: 10209501]
6. Sakane T, Takada S, Kotani H, Tsunematsu T. Effects of methyl-B12 on the in vitro immune functions of human T lymphocytes. J Clin Immunol. 1982 Apr;2(2):101-9 [PMID: 6461666]
7. Okuda K. Yashima K, Kitazaki T, Takara I. Intestinal absorption and concurrent chemical changes of methylcobalamin. J Lab Clin Med 1973;81:557-567 [PMID: 4696188]
8. Sato, Y, Honda Y, Iwamoto, J, Kanoko, T, Satoh, K,. Effects of folate and mecocobalamin in hip fracture in patients with stroke. JAMA 2005;293(9):1082-1088 [PMID: 15741530]
9. Sato, etal. Amelioration by mecobalamin of subclinical carpal tunnel syndrome involving unaffected limbs in stroke patients. J Neurol Sci, 2005;231(1-2):13-18). [PMID: 15792815]
10. Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan. 2005 Jun;14(2):48-54 [PMID: 16008162]
11. Takasaki Y, Moriuchi Y, Tsushima H, Ikeda E, Koura S, Taguchi J, Fukushima T, Tomonaga M, Ikeda S. [Effectiveness of oral vitamin B12 therapy for pernicious anemia and vitamin B12 deficiency anemia] Rinsho Ketsueki. 2002 Mar;43(3):165-9. [PMID: 11979747]
12. Poloschek CM, Fowler B, Unsold R, Lorenz B.Disturbed visual system function in methionine synthase deficiency. Graefes Arch Clin Exp Ophthalmol. 2005 May;243(5):497-500. [PMID: 15931548]
13. James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004 Dec; 80(6):1611-7 [PMID: 15585776]
14. Yamada N. Treatment of recurrent hypersomnia with methylcobalamin (vitamin B12): a case report. Psychiatry Clin Neurosci. 1995 Dec;49(5-6):305-7 [PMID: 8726119]
15. Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, Terashima M, Okada T, Kasahara Y Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991 Oct;14(5):414-8. [PMID: 1759094]
Instructions/How to Use:
Dissolve 1 tablet under your tongue daily or as directed by
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