NADH Nicotine Adenine Dinuculeotide Hydride Energy Mitochondrial Cell Booster CNS Motor Performance Enhancer Antiaging Formula
Mitochondrial Energy Booster Brain Muscles Body
Common Uses: NADH regulates electron transport in mitochondria for making high energy storage NADH reduced for cellular energetics
Instructions/How to Use: Take one tablet twice per day
Ingredients: Nicotine Adenine Dinucleotide Hydride
DESCRIPTION NADH is an exciting nutritional advancement that promotes improved physical energy and mental sharpness. A naturally occurring coenzyme, NADH helps cells become more energized to promote a stronger and more vitalized body.
Item number: AM180 Delivery system: Tablets Amount per bottle: 60 tablets Serving size: 1 tablet 5mg INGREDIENTS PER SERVING NADH (nicotinamide adenine dinucleotide) NADH (nicotinamide adenine dinucleotide) 5 mg Baking Soda 3 mg Vitamin C 0.3 mg
Other ingredients: D-Mannitol, Microcrystalline Cellulose, Magnesium Stearate. SPECIAL DIETARY USEFULNESS This product may have special dietary usefulness, under a physician’s supervision, for patients diagnosed with Chronic physician’s supervision, for patients diagnosed with Chronic Fatigue Syndrome (CFS). MECHANISM OF ACTION NADH is the reduced form of NAD (nicotinamide adenine NADH is the reduced form of NAD (nicotinamide adenine dinucleotide), a coenzyme necessary to dehydrogenate primary and secondary alcohols. In dehydrogenation, NAD acts as a hydrogen acceptor, forming NADH. NADH in turn, serves as a hydrogen donor in the respiratory chain. NADH is an essential intermediate in the cellular processes that generate energy from glucose in the form of ATP. PUBLISHED RESEARCH STUDIES An FDA approved double-blind, placebo controlled clinical trial conducted at Georgetown University Medical Center(1), enrolled twenty-six patients who fulfi lled the U.S. Centers for Disease Control criteria for CFS in 4, 8, and 12 week programs. Subjects were randomly assigned 10mg of NADH per day or placebo for a 4 week period. This was followed by a 4 week wash-out period where subjects gradually received a less potent dose of NADH until they were completely free of NADH. The wash-out period was then followed by another 4 week session in which subjects were crossed over to the alternate treatment program.
The results showed 8 of 26 (31%) of patients responded to NADH, and showed a marked improvement in physical, psychological and neurocognitive measures, in contrast to 2 of 26 (8%) to placebo.
Signifi cantly, 18 of 25 (73%) of the study patients who enrolled in a longer, open label follow-up study, showed signifi cant improvement in clinical symptomatology and energy levels. NADH was also shown to have a good safety record, with none of the subjects experiencing any signifi cant adverse effects.
In another study conducted at the Sleep-Wake Disorders Center at the New York Weil Cornell Medical Center(2), researchers tested the ability of oral stabilized NADH to improve alertness, mood, and performance on cognitive tasks in 25 healthy middle-aged adults after one night of total sleep deprivation.
In this double-blind crossover study, subjects performed signifi cantly better on measures of cognitive performance following one night of total sleep deprivation when they received the NADH supplement compared to placebo. In particular, overall performance effi ciency (number of correct answers per minute) measured one hour after consuming 20mg of sublingual NADH was signifi cantly higher than after placebo. Self-reported alertness, sleepiness (both self-reported and objectively quantifi ed), and mood, did not differ when the subjects consumed NADH or placebo. ADVERSE REACTIONS Side effects may include nervousness and loss of appetite in the fi rst few days after beginning NADH supplementation. No serious side effects have been documented with up to one year of use. Long-term supplementation has not yet been evaluated. RECOMMENDED USE Take one tablet each morning on an empty stomach, 30 minutes before eating, with water only. If you miss a day, do not double use. STORAGE Store in a cool dry place. REFERENCES 1. Forsyth LM, Preuss HG, MacDowell AL, et al. “Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome.” Annals of Allergy, Asthma and Immunology. 1999;82:185-191.
2. Moline ML, Rebeta JL, Flye BL, Zendell SM, Broch L, Ford T, Zak R, Kay GG. “Effectiveness of NADH in Alleviating Effects of Sleep Deprivation in Healthy Middle-Aged Adults.” Abstract presented and published in the proceedings of The First International Conference on Mechanisms of Action of Nutraceuticals, Octorber 2001.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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